Rapid HPLC Analysis for Quantitative Determination of the Two Isomeric Triterpenic Acids, Oleanolic acid and Ursolic acid, in Plantago Major
نویسندگان
چکیده
منابع مشابه
Pharmacology of oleanolic acid and ursolic acid.
Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid has been marketed in China as an oral drug for human li...
متن کاملSimultaneous determination of oleanolic acid and ursolic acid by RP-HPLC in the leaves of Eriobotrya japonica Lindl.
Oleanolic acid (OA) and ursolic acid (UA) are isomeric triterpenic acids and only one methyl's position is different between them. OA and UA always exist in the same plant, so it is difficult to separate them when determining contents by RP-HPLC. In this study, a very simple mobile phase for HPLC was developed to simultaneously determine UA and OA, and the factors affecting separation were also...
متن کاملDetermination of Ursolic Acid and Ursolic Acid Lactone in the Leaves of Eucalyptus tereticornis by HPLC
Um método simples, isocrático, de HPLC foi desenvolvido para quantificação simultânea de dois triterpenos bioativos, ácido ursólico e lactona do ácido ursólico em folhas de E. tereticornis. As amostras foram analisadas em coluna RP-18 (4,6 × 250 mm, 5 μm) com metanol e água acidificada a pH 3,5 com TFA (88:12) a 210 nm. O método foi validado e aplicado para a quantificação simultânea dos triter...
متن کاملEnhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and OA on platelet aggregation was examined on...
متن کاملHost-guest interaction of β-cyclodextrin with isomeric ursolic acid and oleanolic acid: physicochemical characterization and molecular modeling study
Ursolic acid (UA) and oleanolic acid (OA) are insoluble drugs. The objective of this study was to encapsulate them into β-cyclodextrin (β-CD) and compare the solubility and intermolecular force of β-CD with the two isomeric triterpenic acids. The host-guest interaction was explored in liquid and solid state by ultraviolet-visible absorption,1 H NMR, phase solubility analysis, and differential s...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2009
ISSN: 0036-8709
DOI: 10.3797/scipharm.0809-08